Scientist III, Proteomics

Job ID :
Location :
US - New York - Grand Island
Job Description
Scientist III, Proteomics
Requisition ID: 80131BR
When you're part of the team at Thermo Fisher Scientific, you'll do important work, like helping customers in finding cures for cancer, protecting the environment or making sure our food is safe. Your work will have real-world impact, and you'll be supported in achieving your career goals.
Location/Division Specific Information
US ? Grand Island, NY
How will you make an impact?
We are seeking a highly creative scientist with expertise in LC-MS/MS based proteomic profiling to support the development of our product and service offerings for cell culture media and cell line development. The selected candidate will plan and conduct laboratory studies that support the development of novel cell culture media formulations, processes, cell lines, and in silico models.
Designs experimental plans, leads study execution, analyzes experimental data, generates laboratory protocols, and writes technical reports, quantitative analyses, and product summaries
What will you do?
Carries out detailed untargeted and targeted LC-MS/MS analyses of complex and purified proteins. Follows established and develops new protocols, is responsible for new method development, and performs quality control. Tracks and compiles results.
Operates and maintains one or more LC-mass spectrometer systems (e.g. orbitrap LUMOS ETD, triple quadrupole LC-MS/MS systems) and one or more HPLC/UPLC systems for peptide separation, identification and quantification using label-free or TMT, SILAC methods, and post-translational modification analysis.
Works on complex problems of diverse scope where analysis of situations or data requires an in-depth evaluation of various factors
Troubleshoots and solves problems in the design/execution of development projects
Exercises practical judgment within broadly defined practices and policies and exhibits creativity and foresight in selecting approaches and techniques for obtaining solutions
Investigates, creates, and develops new methods and technologies to improve effectiveness of development workflows
Maintains accurate lab notebook to support protection of intellectual property in accordance with relevant Thermo Fisher required standards
Maintains high level of professional expertise and substantial knowledge of principles and theories through familiarity with competing technologies and/or products, review of current scientific literature, and attendance at scientific seminars and meetings
Presents data at scientific conferences (external and internal) and prepares other publications when appropriate
Interacts closely with other internal departments (i.e., Marketing, Business Development, Quality, Operations and/or Technical Services) in the commercialization of new products
Frequent technical interactions with outside collaborators through seminars and publications and with customers through teleconferences, site visits, and scientific meetings
Performs duties independently with only general direction given
Complies with all company safety, training, and quality regulations (e.g., ISO compliance, GLP/GMP requirements, etc.) and procedures
Works in a laboratory environment, is required to lift up to 40 lbs, and may be required to stand for long periods of time while performing duties
Able to work safely with chemicals and hazardous materials
Must be able to work flexible hours; travel may be required as much as 5 ? 10 %
How will you get here?
Bachelor's degree with 5 plus years of experience, Master's degree with 3 plus years of experience, or Ph.D. degree in Chemistry or Biochemistry or other related discipline, or equivalent knowledge and experience.
Minimum Qualifications (must have):
Experience using LC-MS for proteomics analysis, experience in MS-based proteome profiling, interpretation of data, and protein purification/sample preparation is desired
Must possess demonstrated ability and knowledge to design and conduct research independently.
Experience using Mass Spectrometry-software suites (Proteome Discoverer, Peaks Studio, etc) and MS-data analysis tools desired. Experience using Microsoft Office required.
Excellent communication skills and the ability to interact professionally with all levels of staff and external contacts in a fast-paced environment required, and the ability to interpret and summarize scientific results in a clear, concise, and accurate manner.
Demonstrated competence in data analysis, research design, troubleshooting, and the evaluation of new techniques and procedures for manufacturing reagents, systems, products or technologies
Demonstrated ability to identify and solve problems
Excellent organizational skills, including the ability to efficiently evaluate and adapt to changing project priorities
Preferred Qualifications (nice to have):
Expertise in the methods and techniques of small-scale mammalian cell culture, and operation of bench-top stirred tank bioreactors and related process development laboratory equipment.
Working knowledge of scientific principles associated with bioprocessing workflows
Prior industrial experience, particularly in proteomics and/or cell culture media formulation development.
Familiarity with use of bioinformatics tools and visualization software, Metabolic Flux Analysis, and statistical design of experiments (DOE)
Understanding of chemical, biochemical, and physical interactions of cell culture media and reagent components
Prior Industrial experience in continuous bioprocess development for human biotherapeutic applications (perfusion/chemostat-based culture methods).
Previous cell culture experience with cell lines used in protein production applications (e.g. CHO, HEK293, NS0)
Previous experience with cell lines used in the production of viral vaccines or cell therapy (e.g. Vero, MRC-5, BHK; Primary T cells, NK cells)
Experience with sample handling/processing or high-throughput cell culture technologies and other robotic instrumentation (e.g. liquid handling, EvoSep, ambr15)
If you are an individual with a disability who requires reasonable accommodation to complete any part of our application process, click here for further assistance.
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

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